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The use of anabolic steroids has been linked to several types of heart problems, including heart attacks and sudden death. In an editorial, David Katz, MD, of the Mayo Clinic in Arizona, described the findings and called for more research on the drug. "Steroid abuse in bodybuilders has been well established, and there is growing evidence that steroid use leads to an increased risk of other heart-related conditions," Katz wrote. "We want to increase the awareness that anabolic steroids are no laughing matter." The study in New England Journal of Medicine was the first to systematically examine the relationship among more than 4,000 male amateur bodybuilders for heart disease risks. Bodybuilders were divided into 4 groups: no steroid use, steroids and other, combined, or no steroids and other. After the men were randomly assigned by computer to their respective groups, the researchers then tracked their heart-health risk factors for 10 years. The researchers found: Anabolic steroids increased the risk of dying from heart attack. The risk of dying from heart attack rose 2.5 times among bodybuilders using steroids and 2.2 times among those who weren't using steroids, though the increase in mortality for both groups was small. Among male nonusers, there was a small, though not statistically noteworthy, association between using steroids and more strokes. Bodybuilders had a higher risk of dying from any cause. Excess amounts of testosterone (in particular, the testosterone anabolic steroid testosterone norepinephrine deuteride) were risk factors for cardiovascular events, including an increased risk of heart attack and myocardial infarction. Excess testosterone tended to be more protective of cardiovascular diseases than other factors. Men who used steroids at high levels had a decreased ability to survive cardiac events. Bodybuilders were more susceptible to cardiovascular disease from drugs other than steroids. The researchers also said that a causal link is less clear for the other cardiovascular diseases the men had. "There is sufficient evidence for the association between steroids and certain cardiovascular risks, such as an increased risk of heart damage, an increased risk of death in heart attack victims, heart attack mortality, a risk of sudden death and sudden cardiac death, and changes in heart valve function," the authors wrote. The researchers concluded: Our data suggest that in bodybuilders, anabolic steroids may cause heart disease and increase the risk of death from cardiovascular events," Katz said. "However, these associations should be tested. Future studies need to collect information on the number, type and cause of an Similar articles: